Katsanos Meta Analysis Paclitaxel

On the Paclitaxel Meta-Analysis: A Conversation With Konstantinos Katsanos, MD Genetics and Hereditary Factors of Aortic Disease: Applying What We Know, Exploring What We Don’t A discussion on the current landscape of genetics research related to diagnosing and treating aortic disease.

Based on current evidence, the benefits of paclitaxel-coated devices for treatment of peripheral. “However, we strongly encourage our members to discuss the findings of the meta-analysis with their.

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Mar 27, 2019 (Euclid Infotech Ltd via COMTEX) — BD, a leading global medical technology company, today issued the following statement related to the recent letter from FDA to health care providers.

conducted to investigate any potential connection between paclitaxel and mortality. 1. Katsanos K, Spiliopoulos S, Kitrou P, Krokidis M, Karnabatidis D. Journal of the American Heart Association 2018;7:e011245. Patient-Level Meta-Analysis Distribution of Paclitaxel in DCB Group by Tercile

for the purposes of the present meta-analysis. For the Thunder trial (3-arm trial), the arm of paclitaxel dissolved in the contrast medium was excluded. For the ISAR-STATH trial (3-arm trial), the.

Systematic Review and Meta-analysis of Randomized Controlled Trials of Paclitaxel-Coated Balloon Angioplasty in the Femoropopliteal Arteries: Role of Paclitaxel Dose and Bioavailability.

HOLLYWOOD, FL—December 6, 2018, will long loom large in the minds of endovascular experts as the moment when a meta-analysis offered up a startling conclusion: an increase in late death with.

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2 Katsanos K, Spiliopoulos S, Kitrou P, et al. Risk of death following application of paclitaxel-coated balloons and stents in the femoropopliteal artery of the leg: A systematic review and meta.

This marks the second time in less than a week that a major trial of a paclitaxel-coated device for PAD has. PTX on crossover patients who had not been included in the Katsanos meta-analysis. In an.

tus. For the purpose of this network meta-analysis, the search extracted trials comparing primary placement of bare nitinol stents (BNS), covered nitinol stents (CNS), paclitaxel-eluting stents (PES), sirolimus-eluting stents (SES), or paclitaxel-coated balloons (PCB) with BA or with each other in the femoropopliteal artery (Appendix, online only).

13 days ago · Speaking of the JAHA meta-analysis findings, Albrecht and colleagues say that Katsanos et al’s “postulated causality was on the foundation of theoretically-derived paclitaxel doses, which in turn were based on a number of assumptions.”

Our guest editor, Professor William Wijns, has highlighted a selection of the must-see articles on Coronary Artery Disease & Interventional Cardiology from across. J Cardiovasc Pharmacother pvw043.

Additionally, the FDA is urging healthcare providers to report any adverse events or suspected adverse events with paclitaxel-eluting devices through the MedWatch program. The meta-analysis by.

The trial has the longest follow-up of patients randomized to an endovascular device for treatment of femoropopliteal artery disease and has been referenced multiple times in recent months as strong evidence to refute claims linking increased mortality and paclitaxel-based devices in a controversial meta-analysis by Konstantinos Katsanos, MD.

2 Katsanos K, Spiliopoulos S, Kitrou P, et al. Risk of death following application of paclitaxel-coated balloons and stents in the femoropopliteal artery of the leg: A systematic review and meta.

Abbott Northwestern Hospital, a major center for vascular medicine in the Twin Cities, has stopped using medical devices in the legs that contain paclitaxel amid a growing. is that it’s a good.

for the purposes of the present meta-analysis. For the Thunder trial (3-arm trial), the arm of paclitaxel dissolved in the contrast medium was excluded. For the ISAR-STATH trial (3-arm trial), the.

As pointed out by Katsanos, the efficacy of the DCBs in more complex lesions and CLI patients also remains to be determined. “According to a recent meta-analysis of paclitaxel-coated balloons in the.

On Tuesday, Boston Scientific Global Chief Medical Officer Ian Meredith said meta-analyses like the paclitaxel-device study. lead study author Dr. Konstantinos Katsanos of Rion, Greece, stood by.

The FDA’s data followed a meta-analysis published in December in the Journal of the American Heart Association showing a possible increase in mortality after two years in patients treated with.

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Some drug-eluting stents and drug-coated balloons use paclitaxel to prevent blood vessels from reclosing after they’re opened up in medical procedures. But a critical meta-analysis in the Journal of.

2 Katsanos K, Spiliopoulos S, Kitrou P, et al. Risk of death following application of paclitaxel‐coated balloons and stents in the femoropopliteal artery of the leg: A systematic review and.

Their meta regression analysis found a significant link between paclitaxel exposure and absolute risk of death. “Actual causes for this serious late side effect remain unknown, and further investigations with longer-term follow-up are urgently warranted,” Dr. Katsanos and colleagues wrote in their review.

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Paclitaxel-Coated Balloons in the Femoropopliteal Artery It Is All About the Pharmacokinetic Profile and Vessel Tissue Bioavailability* Konstantinos Katsanos, MD, PHD T he femoropopliteal artery remains the‘lion’s den’ for peripheral endovascular procedures because of its unique biomechanical proper-

The trial has the longest follow-up of patients randomized to an endovascular device for treatment of femoropopliteal artery disease and has been referenced multiple times in recent months as strong evidence to refute claims linking increased mortality and paclitaxel-based devices in a controversial meta-analysis by Konstantinos Katsanos, MD.

Konstantinos Katsanos (Patras, Greece) tells Interventional News about new data from a meta-analysis that has been published in the Journal of the American Heart Association (JAHA) that suggest there is an increased risk of death at two and five years following the use of paclitaxel-coated balloons and stents in the femoropopliteal artery.

Many of you are aware of the recent clinical debate on the safety of intravascular devices that use paclitaxel as the active. in December by Dr. Konstantinos Katsanos of Greece. The paper described.

Their meta regression analysis found a significant link between paclitaxel exposure and absolute risk of death. “Actual causes for this serious late side effect remain unknown, and further investigations with longer-term follow-up are urgently warranted,” Dr. Katsanos and colleagues wrote in their review.

SWEDEPAD 1 and SWEDEPAD 2 trials halt inclusion after Katsanos et al’s meta-analysis on paclitaxel-coated devices and interim safety analysis. 11th December 2018. UK MHRA forms Expert Advisory Group to review paclitaxel devices while US FDA updates letter to healthcare providers.

2 Katsanos K, Spiliopoulos S, Kitrou P, et al. Risk of death following application of paclitaxel‐coated balloons and stents in the femoropopliteal artery of the leg: A systematic review and.

In early December 2018, a meta-analysis of 28 trials of paclitaxel DES or DCBs in PAD patients led by Konstantinos Katsanos, MD, PhD (Patras University Hospital, Rion, Greece), reported a 68% relative.

Konstantinos Katsanos (Patras, Greece) tells Interventional News about new data from a meta-analysis that has been published in the Journal of the American Heart Association (JAHA) that suggest there is an increased risk of death at two and five years following the use of paclitaxel-coated balloons and stents in the femoropopliteal artery.

White Led by Konstantinos Katsanos, MD, PhD (Patras University Hospital, Rion, Greece), the meta-analysis of 28 trials set off alarms. there was a 68% relative risk increase in all-cause death with.

2018 Aug; 275: 379–381. 2 Katsanos K, Spiliopoulos S, Kitrou P, et al. Risk of death following application of paclitaxel-coated balloons and stents in the femoropopliteal artery of the leg: A.

The focus was on the scrutiny that paclitaxel-coated devices have received since a meta-analysis by Konstantinos Katsanos, MD, PhD, MSc, EBIR, of Patras University Hospital, Greece, and colleagues, published Dec. 6, 2018, in the Journal of the American Heart Association.

tus. For the purpose of this network meta-analysis, the search extracted trials comparing primary placement of bare nitinol stents (BNS), covered nitinol stents (CNS), paclitaxel-eluting stents (PES), sirolimus-eluting stents (SES), or paclitaxel-coated balloons (PCB) with BA or with each other in the femoropopliteal artery (Appendix, online only).

While thought provoking, this meta-analysis did not take into account patient. determined that no deaths were related to IN.PACT DCB or paclitaxel" studied out to one year." Dr. Konstantinos.

WASHINGTON — There is a safety signal with paclitaxel. by Konstantinos Katsanos, MD, of Patras University Hospital in Rio, Greece. In February, a group defended the safety of Medtronic’s IN.PACT.